Search results for " Will"
showing 10 items of 281 documents
Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2.
2016
The symbiotic gut microbiota play pivotal roles in host physiology and the development of cardiovascular diseases, but the microbiota-triggered pattern recognition signaling mechanisms that impact thrombosis are poorly defined. In this article, we show that germ-free (GF) and Toll-like receptor-2 (Tlr2)-deficient mice have reduced thrombus growth after carotid artery injury relative to conventionally raised controls. GF Tlr2-/- and wild-type (WT) mice were indistinguishable, but colonization with microbiota restored a significant difference in thrombus growth between the genotypes. We identify reduced plasma levels of von Willebrand factor (VWF) and reduced VWF synthesis, specifically in he…
Gianfrancesco Maineri, Paolo da San Leocadio i la gènesi d?un model de Crist portacreu
2020
[CA] El present article es centra en la vinculació entre els diversos exemplars de Crist portacreu de Gianfrancesco Maineri i els homònims de Paolo da San Leocadio. A través de diverses comparacions, tractarà d¿explicar-se la gènesi d¿aquest model, aportant, a més, dades que permetran una millor classificació dels exemplars leocadians. Finalment, es realitzen una sèrie de reflexions entorn de l¿hipotètic retorn de San Leocadio a Itàlia (1485-1489) i a la seua possible vinculació amb Maineri.
How representative are referendums? Evidence from 20 years of Swiss referendums
2017
Direct democracy allows citizens to reverse decisions made by legislatures and even initiate new laws which parliaments are unwilling to pass, thereby, as its proponents argue, leading to more representative policies than would have obtained under a purely representative democracy. Yet, turnout in referendums is usually lower than in parliamentary elections and tends to be skewed towards citizens of high socio-economic status. Consequently, critics of direct democracy argue that referendum outcomes may not be representative of the preferences of the population at large. We test this assertion using a compilation of post-referendum surveys encompassing 148 national referendums held in Switze…
Self-knowledge, Authenticity and Obedience
2014
In questo articolo propongo un descrizione del privilegio epistemico dato alla prospettiva della prima persona, alla quale si relaziona un certo tipo di potere su sé stessi. Vorrei mettere in discussione il punto di vista di Robert Dumm e Richard Moran sul problema del soggetto e abbozzare un approccio alternativo. A tal fine, vorrei per prima cosa avvalermi delle nozioni di Bernard William di riconoscimento e di donazione di senso e, in secondo luogo, utilizzare la distinzione di Simone Weil tra i due sensi di obbedienza e la nozione, ad essa associata, di attenzione. In contrasto con la visione di Moran e Dunn, concluderei affermando che un certo tipo di autopercezione è centrale nel nost…
The Gut Microbiota as an Influencing Factor of Arterial Thrombosis
2018
The mutualistic gut microbiota does not only impact the development and function of various immune cell types, but it also influences the function of the hepatic vascular endothelium and prothrombotic platelet function. With germ-free mouse models, we have demonstrated that gut-derived microbial-associated molecular patterns could stimulate hepatic von Willebrand factor (VWF) synthesis and plasmatic VWF levels through Toll-like receptor-2 (TLR2), thus defining the extent of platelet deposition to the subendothelial matrix of the ligation-injured common carotid artery. In addition to the microbiota-derived choline metabolite trimethylamine N-oxide and the microbiota's regulatory role on the …
Efficacy and safety of Wilate in paediatric VWD patients under 6 years of age - results of a prospective multicentre clinical study including recover…
2013
Treatment with exogenous von Willebrand factor (VWF) is indicated in patients with von Willebrand disease (VWD) in whom treatment with 1-deamino-8-d-arginine vasopressin/desmopressin is contraindicated. Wilate is a new generation plasma-derived concentrate of native VWF and coagulation factor VIII (FVIII) (in a physiological 1:1 ratio) developed for the treatment of VWD. This is the first study to report safety, efficacy and in vivo recovery (IVR) data from 15 paediatric patients less than 6 years of age who received Wilate for either prophylaxis, on-demand treatment or for treatment in surgical procedures during a prospective open-label trial (VWD type 1: 5, type 2A: 1, type 2B: 2, type 3:…
Coagulation and inflammation in long‐term cancer survivors: results from the adult population
2018
Essentials The increase of cancer survival remains curtailed by cardiovascular mortality. We studied a large range of inflammatory and coagulation biomarkers in long-term cancer survivors. Cancer history has an important impact on mortality independent of cardiovascular risk factors. Fibrinogen and von Willebrand factor are potential biomarkers in survivors of increased mortality. Summary Background The advances in cancer treatment and detection of early cancer have resulted in a steady increase in the number of of cancer survivors over the years. However, because of the long-term toxic effects of chemotherapy and radiotherapy, the incidence of cardiovascular disease (CVD) is increasing in …